N-[4-(b-d-Galactopyranosyl)-3-nitrobenzyloxycarbonyl]daunomycin was synthesized as a neutral prodrug of daunomycin. Although stable in 0.05 M phosphate buer, pH 7.4 at 37 C, it was rapidly converted to daunomycin and 3-nitro-4-hydroxybenzyl alcohol under the same conditions in the presence of E. col
✦ LIBER ✦
β-galactoside prodrugs of doxorubicin for application in antibody directed enzyme prodrug therapy/prodrug monotherapy
✍ Scribed by HariKrishna Devalapally; Raghavendra Swamy Navath; Venkateshwarlu Yenamandra; RaghuRam Rao Akkinepally; Rama Krishna Devarakonda
- Book ID
- 105672965
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 999 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0253-6269
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