The synthesis of a novel enediyne 2, and its cytotoxicity and activation by the nitroreductase enzyme NR2 from Esherichia coli B, are described. In contrast to closely related analogues, 2 exhibits a 90-fold increase in cytotoxicity against UV4 cells in the presence of the enzyme and NADH, suggestin
โฆ LIBER โฆ
Self-Immolative Prodrugs: Candidates for Antibody-Directed Enzyme Prodrug Therapy in Conjunction with a Nitroreductase Enzyme
โ Scribed by Mauger, Anthony B.; Burke, Philip J.; Somani, Hanif H.; Friedlos, Frank; Knox, Richard J.
- Book ID
- 120229552
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 821 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-2623
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