β-Chain Extension: A New Mode of Carbon-Carbon Bond Formation and Chain Extension by Polyketide Synthases

Base-catalysed alkylations and conjugate

Base-catalysed alkylations and conjugated additions of α-cyanoenamines : A method for chain extension at the β-carbon of tertiary amides

✍ Brigitte Lesur; José Toye; Marianne Chantrenne; Léon Ghosez 📂 Article 📅 1979 🏛 Elsevier Science 🌐 French ⚖ 212 KB

Anions derived fromcl-cyan oenamines which are readily available from tertiary ami- des, react at the y-carbon atom with alkylating agents and cl-enones. In 1975, two of us described(') a practical one-pot procedure for the conversion of tertiary amides J. into a-cyanoenamines 2.