β-cell GLUT-2 loss and non-insulin-dependent diabetes mellitus: Current status of the hypothesis
✍ Scribed by Milburn, Joseph L. ;Ohneda, Makoto ;Johnson, John H. ;Unger, Roger H.
- Book ID
- 112073468
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 541 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0742-4221
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In order to determine the possible contribution of the GLUT1 (HepG2) glucose transporter gene to the inheritance of non-insulin-dependent diabetes mellitus (NIDDM), two restriction fragment length polymorphisms (RFLPs) and the related haplotypes at this locus were studied in 48 Italian diabetic pati
The liver/islet glucose transporter (GLUT2) is expressed in the liver and in the Beta cells of pancreatic islets and is a candidate gene for the inherited defect in Type 2 (non-insulin-dependent) diabetes mellitus. A series of restriction fragment length polymorphisms have been identified using a GL
Patients with Type 2 (non-insulin-dependent) diabetes mellitus and a strong family history of the disease may represent a sub-group where genetic factors play a preeminent role in transmission of the disease. A defect in the liver/islet cell glucose transporter (GluT 2) could explain many of the pat