In order to determine the possible contribution of the GLUT1 (HepG2) glucose transporter gene to the inheritance of non-insulin-dependent diabetes mellitus (NIDDM), two restriction fragment length polymorphisms (RFLPs) and the related haplotypes at this locus were studied in 48 Italian diabetic pati
Polymorphisms at the GLUT2 (β-cell/liver) glucose transporter gene and non-insulin-dependent diabetes mellitus (NIDDM): analysis in affected pedigree members
✍ Scribed by Marco G. Baroni; Juan C. Alcolado; Paolo Pozzilli; Maria G. Cavallo; Shu-Ri Li; David J. Galton
- Book ID
- 115091346
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 521 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0009-9163
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Despite the strong evidence for a major role played by genetic factors in the aetiology of non-insulindependent diabetes mellitus (NIDDM), the genes involved are still unknown. Association studies of candidate genes for the inheritance of NIDDM have so far yielded inconclusive results. Some evidence
Patients with Type 2 (non-insulin-dependent) diabetes mellitus and a strong family history of the disease may represent a sub-group where genetic factors play a preeminent role in transmission of the disease. A defect in the liver/islet cell glucose transporter (GluT 2) could explain many of the pat