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β-Catenin (Ctnnb1) Gene Mutations in Diethylnitrosamine (DEN)-induced Liver Tumors in Male F344 Rats

✍ Scribed by Yamada, Yasuhiro ;Yoshimi, Naoki ;Sugie, Shigeyuki ;Suzui, Masumi ;Matsunaga, Kengo ;Kawabata, Kunihiro ;Hara, Akira ;Mori, Hideki

Book ID: 108581793
Publisher: Wiley (Blackwell Publishing)
Year: 1999
Tongue: English
Weight: 329 KB
Volume: 90
Category: Article
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1999.tb00822.x

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## Abstract There is growing interest in β‐catenin and its role in various human cancers. We recently reported that 2‐amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ)‐ and 1,2‐dimethylhydrazine (DMH)‐induced colon tumors in the rat contain mutations in __Ctnnb1__, the gene for β‐catenin, but the muta