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Sequencing of the rat β-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline

✍ Scribed by Qingjie Li; Brian M Dixon; Mohamed Al-Fageeh; Carmen A Blum; Roderick H Dashwood


Book ID
117520687
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
442 KB
Volume
283
Category
Article
ISSN
0378-1119

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## Abstract There is growing interest in β‐catenin and its role in various human cancers. We recently reported that 2‐amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ)‐ and 1,2‐dimethylhydrazine (DMH)‐induced colon tumors in the rat contain mutations in __Ctnnb1__, the gene for β‐catenin, but the muta