The base pair substitution mutational profiles in-position (CCCrCTC; 96-99% of total). Base substiduced by the heterocyclic amine cooked food muta-tution mutagenesis induced by heterocyclic amines gens PhIP and IQ in Salmonella typhimurium strains related to PhIP is generally SOS-dependent, requir-T
Absence of p53 Mutations in Rat Colon Tumors Induced by 2-Amino-6-methyldipyrido[1,2-a:3′, 2′-d]imidazole, 2-Amino-3-methylimidazo[4,5-f]quinoline, or 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
✍ Scribed by Makino, Hiroshi ;Ushijima, Toshikazu ;Kakiuchi, Hideki ;Onda, Masahiko ;Ito, Nobuyuki ;Sugimura, Takashi ;Nagao, Minako
- Book ID
- 108580835
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1994
- Tongue
- English
- Weight
- 315 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0910-5050
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2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3
## Abstract 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline (IQ) and 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__)]pyridine (PhIP) are two members of a family of carcinogenic heterocyclic amines (HAs) found in cooked meats that form DNA adducts after activation to __N__‐acetoxy derivatives. The ability of IQ
## Abstract The distribution of the adducts of the cooked meat‐derived heterocyclic amines 2–amino‐3–methylimidazo 4,5–__f__lquinoline (a) and 2–amino‐1–methyl‐6–phenylimidazo[4,5–__b__]pyridine (a) was examined in the __supF__ gene of PSP 189 by a polymerase‐arrest assay using thermal‐cycle sequen
## Abstract 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__]pyridine(PhlP) is the most abundant of the heterocyclic amines, a group of potent carcinogens contained in cooked meat and fish. Female F344 rats fed a diet containing 100 or 400 ppm PhIP developed mammary carcinomas within 104 or 52 wk, respec