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β-Amyloid precursor protein is detectable on monocytes and is increased in Alzheimer’s disease

✍ Scribed by Sonia S Jung; Serge Gauthier; Neil R Cashman

Book ID
117414429
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
181 KB
Volume
20
Category
Article
ISSN
0197-4580

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Progressive cerebral deposition of ␤-amyloid peptide either in blood vessels or around neurites is one of the most important features of Alzheimer's disease (AD). The ␤-peptide, known as A␤ or A4, is produced by proteolytic cleavage of the amyloid precursor protein (APP). Two APP processing pathways