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β-Amyloid induces the production of active, matrix-degrading proteases in cultured rat astrocytes

✍ Scribed by Suman Deb; J. Wenjun Zhang; Paul E. Gottschall

Book ID
113999226
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
877 KB
Volume
970
Category
Article
ISSN
0006-8993

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## Abstract Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that β‐amyloid peptide induces inflammatory‐like responses in astrocytes, leading to neuronal pathology. Reactive astrocytes up‐regulate nerve growth facto