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β-amyloid increases choline conductance of PC12 cells: possible mechanism of toxicity in Alzheimer's disease

✍ Scribed by Zygmunt Galdzicki; Ryuichi Fukuyama; Kishena C. Wadhwani; Stanley I. Rapoport; Gerald Ehrenstein


Book ID
115804691
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
396 KB
Volume
646
Category
Article
ISSN
0006-8993

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## Abstract Neuronal pathology of the brain with Alzheimer's disease (AD) is characterized by numerous depositions of amyloid‐β peptides (Aβ). Aβ binding to the 75‐kDa neurotrophin receptor (p75NTR) causes neuronal cell death. Here we report that Aβ causes cell death in neuronal hybrid cells transf