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421 The mechanism of amyloid β-Peptide (1–42) toxicity in PC12 cells

✍ Scribed by M. Fagarasan; S. Efthimiopoulos

Book ID
117413990
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
136 KB
Volume
17
Category
Article
ISSN
0197-4580

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## Abstract Amyloid β peptide (Aβ) is implicated in the pathogenesis of Alzheimer's disease (AD). The peptide is toxic to neurons, possibly by causing initial synaptic dysfunction and neuronal membrane dystrophy, promoted by increased cellular Ca^2+^. Calpain (Ca^2+^‐dependent protease) and caspase