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α4/7-conotoxin Lp1.1 is a novel antagonist of neuronal nicotinic acetylcholine receptors

✍ Scribed by Can Peng; Yuhong Han; Tanya Sanders; Geoffrey Chew; Jing Liu; Edward Hawrot; Chengwu Chi; Chunguang Wang


Book ID
116831692
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
922 KB
Volume
29
Category
Article
ISSN
0196-9781

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## Abstract α‐Conotoxins, from cone snails, and α‐neurotoxins, from snakes, are competitive inhibitors of nicotinic acetylcholine receptors (nAChRs) that have overlapping binding sites in the ACh binding pocket. These disulphide‐rich peptides are used extensively as tools to localize and pharmacolo