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α1-antitrypsin deficiency

✍ Scribed by James K Stoller; Loutfi S Aboussouan

Book ID: 117289697
Publisher: The Lancet
Year: 2005
Tongue: English
Weight: 353 KB
Volume: 365
Category: Article
ISSN: 0140-6736
DOI: 10.1016/s0140-6736(05)66781-5

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Liver disease related to a-l-antitrypsin deficiency occurs only in Pi ZZ homozygous children. Eleven per cent of Pi ZZ infants present with prolonged neonatal cholestasis. In our group, 25 of 45 Pi ZZ infants with prolonged neonatal cholestasis presented with later cirrhosis. Persistence of jaundice