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α(1-3)-Galactosyltransferase Inhibition Based on a New Type of Disubstrate Analogue

✍ Scribed by Bernhard Waldscheck; Markus Streiff; Wolfgang Notz; Willy Kinzy; Richard R. Schmidt

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
132 KB
Volume
40
Category
Article
ISSN
0044-8249

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✦ Synopsis

How do retaining glycosyltransferases function? To answer this question, UDP-Gal and galactose were covalently linked to form disubstrate analogues 1, of which surprisingly 1β and not 1α inhibited α(1-3)-galactosyltransferases very well. An understanding of this inhibition is a key to the pharmacological prevention of hyperacute rejection in pig to primate xenotransplantation.

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