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α-Tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1

✍ Scribed by Renata Alleva; Maria Serena Benassi; Marco Tomasetti; Nina Gellert; Francesca Ponticelli; Battista Borghi; Piero Picci; Jiri Neuzil


Book ID
116290515
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
602 KB
Volume
331
Category
Article
ISSN
0006-291X

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## Abstract α‐Tocopheryl succinate (TOS), a vitamin E analog, is a promising anticancer agent due to its abilities to inhibit proliferation and to induce apoptosis in a variety of human malignant cell lines, while being relatively less active toward normal cells. However, the molecular mechanisms u