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α-methyl amino acids by catalytic phase-transfer alkylations

✍ Scribed by Martin J. O'Donnell; Brigitte LeClef; David B. Rusterholz; Léon Ghosez; Jean-Pierre Antoine; Mirtha Navarro

Publisher: Elsevier Science
Year: 1982
Tongue: French
Weight: 195 KB
Volume: 23
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)88719-5

No coin nor oath required. For personal study only.

✦ Synopsis

The a-methyl amino acids, a-methyl p-chlorophenylalanine, a-methyl p-tyrosine, amethyl m-tyrosine and a-methyl DOPA have been prepared in good yields from amino ester hydrochlorides.

The key step in the method is the catalytic phase-transfer alkylation of Schiff base derivatives of monoalkyl amino acids.

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