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α-LNA (Locked Nucleic Acid with α-D-Configuration): Synthesis and Selective Parallel Recognition of RNA

✍ Scribed by Poul Nielsen; Nanna K. Christensen; Jakob K. Dalskov

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 224 KB
Volume: 8
Category: Article
ISSN: 0947-6539
DOI: 10.1002/1521-3765(20020201)8:3<712::aid-chem712>3.0.co;2-0

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✦ Synopsis

Alpha-LNA is presented as a stereoisomer of LNA (locked nucleic acid) with alpha-D-configuration. Three different approaches towards the thymine alpha-LNA monomer as well as the 5-methylcytosine alpha-LNA monomer are presented. Different alpha-LNA sequences have been synthesised and their hybridisation with complementary DNA and RNA has been evaluated by means of thermal stability experiments and circular dichroism spectroscopy. In a mixed pyrimidine sequence, alpha-LNA displays unprecedented parallel-stranded and selective RNA binding. Furthermore, a remarkable selectivity for hybridisation with RNA over DNA is indicated.

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