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α-Conotoxin analogs with enhanced affinity for nicotinic receptors and acetylcholine-binding proteins

✍ Scribed by Victor I. Tsetlin; Igor E. Kasheverov; Maxim N. Zhmak; Yuri N. Utkin; Catherine A. Vulfius; August B. Smit; Daniel Bertrand


Book ID
111640019
Publisher
Humana Press Inc
Year
2006
Tongue
English
Weight
57 KB
Volume
30
Category
Article
ISSN
0895-8696

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## Abstract α‐Conotoxins, from cone snails, and α‐neurotoxins, from snakes, are competitive inhibitors of nicotinic acetylcholine receptors (nAChRs) that have overlapping binding sites in the ACh binding pocket. These disulphide‐rich peptides are used extensively as tools to localize and pharmacolo