Several alkyl-and O-methylated-3,4 -dephostatin were synthesized and evaluated for their inhibitory activity toward protein tyrosine phosphatase. Alkyl chains with a length up to that of the pentyl group gave tolerable inhibition, whereas methylation of hydroxyl groups resulted in a decrease in the
✦ LIBER ✦
α-Bromoacetophenone derivatives as neutral protein tyrosine phosphatase inhibitors: structure–Activity relationship
✍ Scribed by Gulnur Arabaci; Tian Yi; Hua Fu; Mary E. Porter; Kirk D. Beebe; Dehua Pei
- Book ID
- 108477316
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 121 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0960-894X
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