α-Amino Acids and Derivatives in the Asymmetric Synthesis of Tetrahydroisoquinoline Alkaloids
✍ Scribed by Jose L. Vicario; Dolores Badia; Luisa Carrillo; Juan Etxebarria
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 52 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract Asymmetric alkylation of (__S__)‐Boc‐BMI (**1a**, BMI = 2‐__tert__‐butyl‐3‐methylimidazolidin‐4‐one) and its α‐methyl derivative **1b** with 2‐fluoroallyl tosylate, subsequent mild acidic deprotection of the products **2a** and **2b**, and basic hydrolysis of the thus formed __N__‐methy
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the product of Eq. 1 should have the S,S configuration and not the R,R configuration shown.