α-Amanitin-resistant mutants of Chinese hamster ovary (CHO) cells
✍ Scribed by K.C. Gupta; M.W. Taylor
- Book ID
- 113191319
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 383 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0027-5107
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## Abstract Stable clones selected for resistance to tunicamycin (TM) have been isolated from Chinese Hamster Ovary (CHO) cells. The TM^R^ phenotype is stable for more than nine months in the absence of the drug. The morphology of TM^R^ mutant varies from epitheloid to abnormally elongate. The muta
Isolation and characterization of Chinese hamster ovary cell mutants resistant to different DNA polymerase inhibitors (aphidicolin, ara-A and ara-C) have been described. A particular mutant (JK3-1-2A) characterized in detail was found to grow and synthesize DNA in medium containing an amount of aphi