Über β-Lactame, V. Zur Darstellung einiger kondensierter β-Lactame
✍ Scribed by Paul, Lieselotte ;Polczynski, Peter ;Hilgetag, Günter
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1967
- Tongue
- English
- Weight
- 318 KB
- Volume
- 100
- Category
- Article
- ISSN
- 0009-2940
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Die Athanolyse des 1-Lactams von 2-Thio-hydantoin-[P-propionsaure]-(5) 1 (n=2) in Gegenwart von Triathylamin verlauft anomal unter Offnung des Thiohydantoinrings zu dem Thiocarbamoylester der Struktur 4. Umsetzung des Lactams rnit HN3 bei 150" und darauffolgende saure Hydrolyse liefert ccy-Diarnino-
## Abstract ‘7‐aminocephalocillanic acid’ **1**, an intermediate for the preparation of new β‐lactam antibiotics was prepared by transforming the β‐lactam carbinol **2a** to the phosphorane **9a** through several steps. Oxydation of **9a** with DMSO/Ac~2~O led directly to the cyclized ester **11a**
## Abstract Benzhydrylic esters of 3‐unsubstituted cephem‐4‐carboxylic acids of types **9** and **10** (__Scheme 2__) are prepared by decarbonylation of esters of 3‐formylcephem compounds of type **2** with tris‐triphenylphosphine‐rhodium chloride. The preparation of the starting materials **2** an