Über die Reduktion ungesättigter Fettsäuren und deren Ester zu ungesättigten Fettalkoholen durch selektive katalytische Hochdruckhydrierung IV: Oxidische kupfer- und cadmiumhaltige Kontakte

✍ Scribed by Bertsch, H. ;Reinheckel, H. ;Haage, K.

• Publisher: John Wiley and Sons
• Year: 1969
• Weight: 680 KB
• Volume: 71
• Category: Article
• ISSN: 0931-5985
• DOI: 10.1002/lipi.19690710908

✦ Synopsis

Sample 1 Sample 2 Sample 3 Sample 4 20 mice 20 mice 20 mice 20 mice 17 dead in 14 dead in 16 dead in 18 dead in 4-5 days, G days, 5 days, 5 days, 3 survived, G survivals, 4 survivals, 2 survivals, All adhesions All adhesions All adhesions All adhesions Group B -Injected with eluate of adsorbate Sample 1 Sample 2 Sample 3 Sample 4 20 mice 20 mice 20 mice 20 mice All dead All dead All dead All dead 48 hours 48 hours 48 hours 48 hours All adhesions All adhesions All adhesions All adhesions Group C -Injected with purified Arlacel A Sample 1 Sample 2 Sample 3 Sample 4 20 mice 20 mice 20 mice 20 mice None dead None dead None dead None dead No adhesions No adhesions No adhesions No adhesions Group D -Injected with normal saline Blank 20 mice None dead No adhesions D i s c u s s i o n Scarcely any mention of the autoxidation of surface active agents and emulsifiers is found in the literature.

No mention of the possible toxicity caused by autoxidised surfactants is found although a large amount of work has been carried out on the toxicity of fats, oils and fatty acids. It has been shown here from Fig. 1 that Arlacel A, a surfactant used in the formulation of water in oil emulsions is readily autoxidisable and that the autoxidation products are toxic.

T h e autoxidation of the oleate moiety of the molecule may be enhanced by the carbohydrate moiety in the molecule of the compound which probably acts as a chelating agent for metals. It has been also shown, that the autoxidised Arlacel A is toxic and that it is possible to purify it by passing through a column of alumina.

Furthermore, it was found that the purified dianhydro mannitol mono-oleate is not toxic and it is comparable to normal saline in its action. The alumina adsorbate, though probably differing in some way from the autoxidised product, is toxic to a greater extent than the autoxidised Arlacel A. Its quantity, however, was not sufficient for both toxicity and identification purposes and it was found preferable to prove at first its toxic action.