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Zuclopenthixol levels in serum and breast milk

✍ Scribed by Tove Aaes-Jørgensen; Flemming Bjørndal; Ulla Bartels

Publisher
Springer
Year
1986
Tongue
English
Weight
155 KB
Volume
90
Category
Article
ISSN
0033-3158

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✦ Synopsis

Breast milk and serum samples were obtained from six psychotic patients 3 days-10 months after delivery. Five of the women were given zuclopenthixol PO daily, and one was given zuclopenthixol decanoate IM every 2 weeks. Zuclopenthixol was estimated in breast milk and serum by high performance liquid chromotography. The zuclopenthixol levels in milk were found to be 29% of the serum levels on average. Based on the drug levels found in milk, the daily dose to a suckling infant was estimated to be 0.5-5 gg zuclopenthixol, corresponding to a dose of 0.01-0.1 mg to an adult. It is not likely that such a low dose would cause any effects or side effects in the infant unless infants are very different from adults concerning metabolism or sensitivity to the drug. The suckling infants included in this study were apparently not influenced by the intake of zuclopenthixol with the milk.

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