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Zone-specific hepatotoxicity of gossypol in perfused rat liver

✍ Scribed by Sunao Manabe; David C. Nuber; Young C. Lin


Book ID
116072810
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
266 KB
Volume
29
Category
Article
ISSN
0041-0101

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The liver glutathione content was measured after oral administration of 1,1-dichloroethylene (vinylidene chloride = VDC; dissolved in olive oil) and its significance for the metabolism and hepatotoxicity of VDC was investigated. After treatment with 1000 mg/kg VDC p.o., glutathione decreased to 33%