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Uptake and hepatotoxicity of 1,1-Dichloroethylene by the isolated blood-perfused rat liver

โœ Scribed by D. Reichert; D. Henschler


Publisher
Springer-Verlag
Year
1978
Tongue
English
Weight
513 KB
Volume
41
Category
Article
ISSN
0340-0131

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The liver glutathione content was measured after oral administration of 1,1-dichloroethylene (vinylidene chloride = VDC; dissolved in olive oil) and its significance for the metabolism and hepatotoxicity of VDC was investigated. After treatment with 1000 mg/kg VDC p.o., glutathione decreased to 33%

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