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Zinc improves the development of human CD34+ cell progenitors towards Natural Killer cells and induces the expression of GATA-3 transcription factor

โœ Scribed by Mario Muzzioli; Rosalia Stecconi; Alessia Donnini; Francesca Re; Mauro Provinciali

Book ID
116307340
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
487 KB
Volume
39
Category
Article
ISSN
1357-2725

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Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus
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GATA-3 is a zinc-finger transcription factor that is essential for both early T cell development and Th2 cell differentiation. To quantify GATA-3 expression during T cell development in vivo in the mouse, the GATA-3 gene was targeted by insertion of a lacZ reporter by homologous recombination in emb