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ZAK re-programs atrial natriuretic factor expression and induces hypertrophic growth in H9c2 cardiomyoblast cells

✍ Scribed by Chih-Yang Huang; Pin Ju Chueh; Chien-Tang Tseng; Kuan-Yu Liu; Hsiao-Ya Tsai; Wei-Wen Kuo; Ming-Yung Chou; Jaw-Ji Yang

Book ID: 116289297
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 933 KB
Volume: 324
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2004.09.156

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## Abstract The IGF‐II/mannose 6‐phosphate receptor (IGF‐IIR/Man‐6‐P) up‐regulation correlates with heart disease progression and its signaling cascades directly trigger pathological cardiac hypertrophy, fibrosis, and cardiomyocytes apoptosis. IGF‐IIR gene expression/ suppression is able to prevent