‘Z-RNA’—a left-handed RNA double helix
✍ Scribed by Hall, Kathleen; Cruz, Phillip; Tinoco, Ignacio; Jovin, Thomas M.; van de Sande, Johan H.
- Book ID
- 109736869
- Publisher
- Nature Publishing Group
- Year
- 1984
- Tongue
- English
- Weight
- 272 KB
- Volume
- 311
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/311584a0
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The Z-form of poly(dG-m5dC)~poly(dG-m5dC) in 85% ethanol/MOPS and the Z-form poly ( rG-rC ) . poly ( rG-rC) in 4.8 M NaClO,, 20% ethanol are studied by flow linear dichroism. Simultaneous analysis of the isotropic absorption and linear dichroism data yields the angle of inclination of the base norma
we have calculated a theoretical counterpart of this idealized double helix by constraining the helical twist and rise to their experimental values ( -45' and 2.33 A, respectively). Applying the same constraints to the parallel-stranded duplex, this also leads to a low-energy structure with wide cen
## Abstract The experimentally observed geometry of a miniature double helix of high __anti__ (χCN fixed ≃ 120°) nucleic acid structure indicates substantial interstrand base stacking with little intrastrand base stacking. This geometry is consistent with the __right__‐__handed vertical double heli