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Comparison of base inclinations for left-handed DNA and RNA

✍ Scribed by Chartchai Krittanai; Hunseung Kang; Xiaokui Jin; Jeannine H. Riazance-Lawrence; W. Johnson Curtis Jr.

Book ID
102774286
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
606 KB
Volume
1
Category
Article
ISSN
1075-4261

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✦ Synopsis

The Z-form of poly(dG-m5dC)~poly(dG-m5dC) in 85% ethanol/MOPS and the Z-form poly ( rG-rC ) . poly ( rG-rC) in 4.8 M NaClO,, 20% ethanol are studied by flow linear dichroism. Simultaneous analysis of the isotropic absorption and linear dichroism data yields the angle of inclination of the base normal relative to the helix axis, and the orientation of the axis around which the bases incline. For the Z-form of poly(dG-m5dC) .poly(dG-m5dC) the inclination angles are 31.3" for guanine, and 27.9" for cytosine; for the Z-form of poly(rG-rC).poly(rG-rC) they are 25.0" for guanine, and 23.3" for cytosine. The inclination angles for the Z-form DNA are similar to those for the Zform, and the angles for Z-form RNA are somewhat smaller. The axes of inclination for guanine and cytosine are similar in all three left-handed forms.

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