XYY syndrome in children with acute lymphoblastic leukemia

✍ Scribed by Sandlund, J.T.; Krance, R.; Pui, C.-H.; Hancock, M.; Crist, W.M.; Filatov, L.V.; Raimondi, S.C.

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 30 KB
• Volume: 28
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199701)28:1<6::aid-mpo2>3.0.co;2-p

✦ Synopsis

Certain constitutional chromosomal abnor-0.001), but not significantly so. This finding and malities increase the risk of malignancy and/or a literature review failed to confirm an increased decrease treatment tolerance. We identified two frequency of the XYY syndrome among children patients with the XYY syndrome among a total with acute lymphoblastic leukemia. Both of our of 444 male children with acute lymphoblastic patients remain in remission 24 and 28 months, leukemia who had complete cytogenetics stud-respectively, postdiagnosis. Their tolerance of ies. In both cases, the leukemic cell karyotype intensive treatment, including high-dose methosuggested a constitutional XYY abnormality that trexate, suggests that the untoward treatment was confirmed in studies of lymphocytes ob-toxicity seen in patients with chromosomal abtained during remission. The incidence rate in normalities such as trisomy 21 does not extend our series is higher than that of the XYY syn-to the XYY syndrome.