A patient with classical Turner's syndrome and a 45,X/47,XYY mosaicism is described. Each cell line was present in approximately equal amounts in the peripheral blood lymphocytes, while in fibroblasts derived from skin and both gonads only the 45,X karyotype was present. It is suggested that the lat
X/X translocation in a patient with Turner's syndrome
โ Scribed by H. Berghe; J. P. Fryns; C. Soyez
- Publisher
- Springer
- Year
- 1973
- Tongue
- English
- Weight
- 259 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0340-6717
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## Abstract The first case of synovial sarcoma in a patient with Turner's syndrome (45,X) is reported. Cytogenetic analysis of the tumor cells showed that the only X chromosome was involved in the t(X;18)(p11;q11) characteristic of synovial sarcoma.
Cytogenetic analyses have previously shown that the region Xq11.2-q21 is retained in all structurally abnormal X chromosomes. From these observations the conclusion has been drawn that this "critical region" on the proximal long arm of the X chromosome contains the locus controlling X-inactivation.