The initial cytogenetic analysis of a biphasic synovial sarcoma showed an apparently normal karyotype. After FISH using chromosome X-and 18-specific probes and RT-PCR using SYT-and SSX-specific primer sets, a cryptic synovial sarcomaassociated t(X;18)(p11;q11) could be revealed. The ''masked'' natur
A synovial sarcoma with t(x;18)(p11;q11) in a patient with turner's syndrome
β Scribed by Monica Miozzo; Gabriella Sozzi; Claudia T. Cariani; Marco A. Pierotti; Gluseppe Della Porta; Silvana Di Palma; Roberto Luksch; Alberto Azzarelli
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 225 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1045-2257
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β¦ Synopsis
Abstract
The first case of synovial sarcoma in a patient with Turner's syndrome (45,X) is reported. Cytogenetic analysis of the tumor cells showed that the only X chromosome was involved in the t(X;18)(p11;q11) characteristic of synovial sarcoma.
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## Abstract A somatic cell hybrid containing the synovial sarcomaβassociated t(X;18)(p11.2;q11.2) derivative (der(X)) chromosome was used to characterize the translocation breakpoint region on the X chromosome. By using Southern hybridization of DNA from this der(X) hybrid in conjunction with Xpβre
A patient with classical Turner's syndrome and a 45,X/47,XYY mosaicism is described. Each cell line was present in approximately equal amounts in the peripheral blood lymphocytes, while in fibroblasts derived from skin and both gonads only the 45,X karyotype was present. It is suggested that the lat