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XRCC3 Controls the Fidelity of Homologous Recombination: Roles for XRCC3 in Late Stages of Recombination

✍ Scribed by Mark A Brenneman; Brant M Wagener; Cheryl A Miller; Chris Allen; Jac A Nickoloff


Book ID
117736873
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
230 KB
Volume
10
Category
Article
ISSN
1097-2765

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XRCC2 and XRCC3 proteins are structurally and functionally related to RAD51 which play an important role in the homologous recombination, the process frequently involved in cancer transformation. In our previous work we show that the 135G>C polymorphism (rs1801320) of the __RAD51__ gene can modify t