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XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks

✍ Scribed by Horton, Julie K; Watson, Mary; Stefanick, Donna F; Shaughnessy, Daniel T; Taylor, Jack A; Wilson, Samuel H

Book ID
109846918
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
711 KB
Volume
18
Category
Article
ISSN
0007-0610

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## Abstract X‐ray cross complementing 1 (XRCC1) protein has been suggested to bind to DNA single‐strand breaks (SSBs) and organize protein interactions that facilitate efficient DNA repair. Using four site‐specifically modified human XRCC1 mutant expression systems and functional complementation as