XO/XY mosaicism and non-fluorescing Y chromosome in a male

✍ Scribed by B. W. Richards; A. Stewart

• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 982 KB
• Volume: 45
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00278731

✦ Synopsis

An adult male of short stature and with underdeveloped external genitalia is described, who carried out a number of sexual assaults on young women. He proved to have XO/XY mosaicism and a non-fluorescing Y chromosome. It was considered to be a terminal deletion on morphological grounds. It is suggested, on the evidence of the small number of XO/XY mosaics examined by appropriate staining methods, that an abnormal Y chromosome, whether terminally deleted or non-fluorescing owing to an altered chemical state, predisposes to anaphase lagging and non-disjunction. Of eleven reported cases of XO/XY mosaicism with a non-fluorescing Y chromosome, this is the fifth of male phenotype. The severe behaviour disturbance of early onset is considered to be probably causally associated with the chromosome anomaly.