Seminoma in a 12-year-old male with 46 XY/45 XO karyotype

✍ Scribed by Donald C. Doll; Stanley Kandzari; Jesse J. Jenkins III; Stephen Amato; Barbara Jones

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 729 KB
• Volume: 42
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197810)42:4<1823::aid-cncr2820420421>3.0.co;2-8

✦ Synopsis

A pure seminoma in a 12-year-old boy with an undescended testis and 46 XYl45 XO karyotype is presented. The relationships between an undescended testis, an abnormal karyotype, dysgenetic gonads and cancer are discussed.

Cancer 42:1823-1825, 1978.

ESTICULAR NEOPLASMS IN infancy and

T childhood are uncommon. They are seventh in frequency among malignant neoplasms in children and account for 1% to 5% of all solid turn or^.'^^^^ A review of selected series revealed that embryonal carcinoma and teratomas are the most frequent testicular tumors while seminoma is reported rarely.lB2*e report a case of seminoma iii an undescended testis in a 12-year-old boy with a 46 XY/45 XO chromosome composition.

5,11,16,17 w CASE REPORT

A 12-year-old white male was referred to the Pediatrics Department for evaluation and treatment of a testicular tumor. At 6 months of age, the patient had a left inguinal hernia repair. At that time a left undescended testis was found but it was thought to be too small to be brought down into the scrotum. He had no problems until