๐”– Bobbio Scriptorium
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XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

โœ Scribed by Yamaguchi, K.


Book ID
111745967
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
350 KB
Volume
18
Category
Article
ISSN
0261-4189

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TAB2, a Novel Adaptor Protein, Mediates
โœ Giichi Takaesu; Satoshi Kishida; Atsushi Hiyama; Kyoko Yamaguchi; Hiroshi Shibuy ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 382 KB

The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negativ