TAB2, a Novel Adaptor Protein, Mediates
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Giichi Takaesu; Satoshi Kishida; Atsushi Hiyama; Kyoko Yamaguchi; Hiroshi Shibuy
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Article
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2000
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Elsevier Science
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English
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The TAK1 MAPKKK mediates activation of JNK and NF-KB in the IL-1-activated signaling pathway. Here we report the identification of TAB2, a novel intermediate in the IL-1 pathway that functionally links TAK1 to TRAF6. Expression of TAB2 induces JNK and NF-kappaB activation, whereas a dominant-negativ