As a result of the x-ray single crystal analysis of N-iodoacetylamphotericin B the chemical and stereochemical absolute structure ia presented (I). A similar etructure and stereochemistry wae extended to the parent compound itself, amphotericin B, a heptaene macrolide antifungal antibiotic possessin
X-ray Structures and Absolute Configurations of the Antibiotics Oligomycins A, B and C: Inhibitors of ATP Synthase
β Scribed by Rex A. Palmer; Brian S. Potter
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 475 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1572-8854
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Tetrahedron Letters No. 41. pp. 3601-3604 (1970) p. 3529 W. Sprenger was omitted from the "Contributors to this issue" W. MECHLINSKI, C. P. SCHAFFNER, P. GANIS and G. AVITABILE: Structure and absolute configuration of the polyene macrolide antibiotic amphotericin B.
The conformational features of the mitotic kinesin Eg5 inhibitor monastrol were investigated by computational (AM1, HF/3-21G β«Ψ‘β¬ ), X-ray diffraction, and NMR studies showing that monastrol is a conformationally highly flexible molecule. Racemic monastrol was resolved by direct enantioselective HPLC
Krivoruchko. -Chem. Abst. 1\_1. 50409 (1969). 9) The C-H long range couplings observed between C-4a (681.6) and 6-H (66.89) and between C-3 (675.3) and 3-CH3 (61.24) indicates that the remaining quaternary oxycarbon (680.2) is assignable to C-12b.