X protein mutations in hepatitis B virus DNA predict postoperative survival in hepatocellular carcinoma
β Scribed by Xie, Ying; Liu, Shufeng; Zhao, Yue; Guo, Zhanjun; Xu, Jinsheng
- Book ID
- 126258798
- Publisher
- S. Karger AG
- Year
- 2014
- Tongue
- English
- Weight
- 271 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1010-4283
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To explore the role of hepatitis B virus (HBV) X protein in liver carcinogenesis, independently from its role in viral replication, we have analyzed X gene structure and expression in tumorous and non-tumorous tissues obtained from 9 hepatitis B surface antigen (HBsAg)-negative, HBV DNApositive pati
Tumour, cirrhotic, and metastatic tissues from four patients with primary hepatocellular carcinoma have been investigated for the presence of hepatitis B viral DNA by nucleic acid hybridization. Tumours from two of three patients with a current HBV infection contained 1--2 genomes per cell of uninte