X-linked mental retardation with heterozygous expression and macrocephaly: Pericentromeric gene localization
✍ Scribed by Turner, G. ;Gedeon, A. ;Mulley, J.
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 553 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0148-7299
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📜 SIMILAR VOLUMES
A gene responsible for X-linked mental retardation with macrocephaly and seizures (MRX38) in a family with five affected males in three generations was localized to Xp21.1-p22.13 by linkage analysis. Recombination events placed the gene between DXS1226 distally and DXS1238 proximally, defining an in
## Linkage analysis was performed on a fourgeneration family with nonspecific mental retardation (MRX59 ). The five affected males, ranging in age from 2 years to 52 years, have a normal facial appearance and mild to severe mental impairment. Four obligate carriers are physically normal and not ret
## Abstract Isolated mental retardation is clinically and genetically heterogenous and may be inherited in an autosomal dominant, autosomal recessive, or X‐linked manner. We report here a linkage analysis in a large family including 15 members, 6 of whom presenting X‐linked non‐syndromic mental ret