X-linked inheritance of Fanconi anemia complementation group B
β Scribed by Meetei, Amom Ruhikanta; Levitus, Marieke; Xue, Yutong; Medhurst, Annette L; Zwaan, Michel; Ling, Chen; Rooimans, Martin A; Bier, Patrick; Hoatlin, Maureen; Pals, Gerard
- Book ID
- 109919071
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 463 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1061-4036
- DOI
- 10.1038/ng1458
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The two genetic complementation groups reported for Fanconi's anemia (FA) correspond to two phenotypic classes as characterized by measurements of the rate of DNA semiconservative synthesis after 8-methoxypsoralen photoaddition. This test allows a rapid genetic classification of FA patients which ap
Fanconi anemia (FA) is a rare autosomal recessive or X-linked disorder characterized by aplastic anemia, cancer susceptibility and cellular sensitivity to DNA crosslinking agents. Eight FA proteins (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM) and three non-FA proteins (FAAP100, FAAP24