X-irradiation injury and repair in the germinal epithelium of male rats II. Injury and repair in immature rats

✍ Scribed by Shaver, Samuel L.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1953
• Tongue: English
• Weight: 1017 KB
• Volume: 92
• Category: Article
• ISSN: 0002-9106
• DOI: 10.1002/aja.1000920304

✦ Synopsis

Adult aiiimals havc becii used almost exclusively for the study of x-irradiation damage to the mammalian testis. Regaud and Dubreuil ('07) reported that spermatogonia of prepubertal rabbits wcrc more susceptible to x-rays than those of adults of this species. Since this early report, thcre seems to be almost a complete absence of literature dealing with this phase of study. Thereforc, it seemed important that the effect of x-rays on immature testes of rats be investigated to obtain a broader understanding of the postirradiation histopathology of this organ, aiid to secure data pertinent t o effects observed in the study of adult testes reported earlier (Shaver, '53). As was shown in the study mentioned (Shaver, '53), both "dust-like ' ' and " crust-like " spermatogonia are remarkably resistant to morphologic injury after total-body irradiation of 500r. Although one might expect this to be true also in immature animals, since spermatogonia at different ages pre-*Based on work performed under contract with the United States Atomic Energy Commission a t the University of Rochester Atomic Energy Project, Rochester, New York.

The studies reported here represent an extension of preliminary studies which were incorporated in a thesis submitted in partial fulfillment of the requirements for the Ph.D. degree.