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X-inactivation patterns in monozygotic and dizygotic female twins

✍ Scribed by Goodship, Judith; Carter, Joan; Burn, John

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 15 KB
Volume: 61
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19960122)61:3<205::aid-ajmg3>3.0.co;2-t

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✦ Synopsis

We have tested the hypothesis that contrasting X-inactivation patterns could be a trigger for monozygotic twinning in females. X-inactivation patterns were studied in umbilical cord tissue in 43 monozygotic twin pairs and 24 dizygotic twin pairs. Very skewed or non-random X-inactivation patterns were observed in both twins in six of the monozygotic twin pairs and in one of the dizygotic twin pairs. Contrasting X-inactivation patterns occurred in only one of the six monozygotic twin pairs. This does not support the original hypothesis. There is a trend to extreme skewing of X-inactivation pattern occurring more frequently in monozygotic twins.

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