Heteroallelic monozygotic twins and triplets
✍ Scribed by Cant�, Jos� M.; D�az-Gallardo, M.Y.; Barros-N��ez, P.; Figuera, L.E.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 5 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0148-7299
- DOI
- 10.1002/(sici)1096-8628(19980501)77:2<166::aid-ajmg11>3.0.co;2-l
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Patterns of X-chromosome inactivation in chorion, amnion, and cord from 79 pairs of twins were examined. Seven sets of triplets were included in the analysis, both as twin pairs and triplets. Twins were stratified as dizygotic (DZ), monozygotic (MZ), monochorionic, and dichorionic and were selected
Deletions within chromosome band 22q11.2 are associated with a variety of conditions, although a simple genotype-phenotype correlation has not been established so far. Environmental factors, chance events, or a second hit theory were supported by two observations of monozygotic twins with 22q11.2 de
We have tested the hypothesis that contrasting X-inactivation patterns could be a trigger for monozygotic twinning in females. X-inactivation patterns were studied in umbilical cord tissue in 43 monozygotic twin pairs and 24 dizygotic twin pairs. Very skewed or non-random X-inactivation patterns wer