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X chromosome defects as a cause of idiopathic familial premature ovarian failure

โœ Scribed by Colin J. Davis; Rina M. Davison; Charles H. Rodeckl; Gerard S. Conway

Book ID
117125244
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
164 KB
Volume
70
Category
Article
ISSN
0020-7292

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## Abstract Since only 20% of female fragile X premutation carriers develop premature ovarian failure (POF, i.e., amenorrhea before age of 40 years), and since X chromosome inactivation (XCI) determines the phenotypic severity of full mutation women, we reasoned that the development of POF in fragi