X chromosome inactivation does not defin
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Marian A. Spath; Willy N. Nillesen; Arie P.T. Smits; Ton B. Feuth; Didi D.M. Bra
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Article
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2010
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John Wiley and Sons
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English
β 159 KB
π 2 views
## Abstract Since only 20% of female fragile X premutation carriers develop premature ovarian failure (POF, i.e., amenorrhea before age of 40 years), and since X chromosome inactivation (XCI) determines the phenotypic severity of full mutation women, we reasoned that the development of POF in fragi