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WT1mutations in patients with Denys-Drash syndrome and wilms’ tumor

✍ Scribed by V. Schumacher; S. Schneider; B. Royer-Pokora


Book ID
112784642
Publisher
Springer-Verlag
Year
1995
Tongue
English
Weight
147 KB
Volume
121
Category
Article
ISSN
1432-1335

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WT1 mutations in patients with Denys-Dra
✍ Agneta Nordenskjöld; Eitan Friedman; Maria Anvret 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 803 KB

Denys-Drash syndrome (DDS) is characterized by early onset nephropathy, pseudohermaphroditism in males and a high risk for developing Wilm's tumour (WT). The exact cause of DDS is unknown but germline mutations in the Wilm's tumour suppressor gene (WT1) have recently been described in the majority o